BMS 632 (02) ENDOCRINOLOGY
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Endocrinology Course Syllabus
(Three Credit-Hours)
Spring 2003
Section (02) 4:00 PM- 7:00 PM Thursday SNHS Bldg. Rm 106
Dr. Yu-Wai Peter Lin MT(ASCP), PhD
Office/Lab: SNHS Bldg. Room 330, Ph: (305) 899-3226
E-mail: plin@mail.barry.edu
Office Hours:
Posted on office door or by appointment
M & W 9:00 AM - 11:30 AM
Evening office hours: Th 7:00 - 7:30 PM or By appointment
Endocrinology Class Distribution List (Bucmail): BMS-632-02-0301@mail.barry.edu
How do I send email directly without searching the global address book ?
The class list addresses are created using the following format:
Course-ID-Section-YearTerm@mail.barry.edu
For example, Accounting 336 01 held in Fall 2001 would have ACC-336-01-0101@mail.barry.edu as the e-mail address.
Will everyone be able to send messages to my class list ?
No, only members (students registered in the course) of the list will be able to send to the class list. Instructors are added as members to the class list, allowing them to send messages.
CELEBRATING STUDENT EXCELLENCE; KNOWLEDGE EMPOWERS
MARC U*STAR Celebrates 20th Anniversary at Barry
February 13, 2003
MARC Symposium Registration
March 20, 2003
Dr. Richard Falvo
Click on the slide below to preview Dr. Falvo's presentation
 | Course (Endocrinology) Outline | ||||||||||||
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| Class Schedule
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| Message Center |
| Glossary (NHGRI-NIH) |
| Links and Assignments |
| Bookmarks |
| Copyright Acknowledgement |
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Presentation of reports, discussions, lectures, and papers on selected topics in endocrinology. To provide an in-depth study of the current topics in endocrinology. Use of in-vitro oocyte culture (a well established neuroendocrine model), library research and Internet resources to elucidate the cellular and molecular mechanisms regulating the endocrine, paracrine and autocrine functions of pituitary-gonadal axis.
| Goals and Objectives: |
Goals -- The major goal is acquiring an understanding of current theories of mechanisms of endocrine functions and their implications for both basic knowledge and its application in modern medicine. A secondary aim is to familiarize students with current scientific literature and the use of the vast endocrine and biomedical resources on the World Wide Web, for research.
Objectives -- Upon completion of this course the student will be able to:
1. Identify the chemical nature of the major hormones.2. Describe how this chemical nature influences hormone synthesis, transport, storage, mechanism and site of action, and appropriate route of exogenous hormone administration.
3. Describe the major theories for the mechanism of hormone action and list those hormones that are identified predominantly with each of these mechanisms.
4. Explain the impact of hormonal rhythms on endocrine function.
5. Increase analytical skills by reading, interpreting and discussing current scientific literature in the field of endocrinology.
| Text: |
Susan P. Porterfield
Mosby- Year Book, Inc. St. Louis, Missouri. Second Edition 2001
ISBN 0-323-01128-4
The Biology Place (Reference)
The Biology Place, a web learning environment that includes learning activities, study and testing aids, and a wide range of content to help you succeed in your course.
Student Subscription Options: You can purchase a subscription to Biology Place online and pay by credit card to gain immediate access. If you are ordering by check through the mail, a mail order form will be generated for you at the end of the process. To order, please click on the link below.
https://k2.peregrine-pub.com/center/subscribe.html
© 1998, 1997 Peregrine Publishers, Inc. All rights reserved.
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Human Endocrinology |
http://www.biology.com/kimball/kimball.html?maincontent=H/Hormones.html
Handbook of Endocrinology, Vol. II (Reference)
Edited by George H. Gass and Harold M. Kaplan
CRC Press, Inc. New York. Second Edition 1996.
ISBN 0-8493-9430-9
Hormones (Reference)
Anthony W. Norman and Gerald Litwack
Academic Press, San Diego, California. Second Edition 1997.
ISBN 0-12-521441-3
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Computer assignments (HyperCELL), internet connection to biology web site on the World Wide Web (The Biology Place), online journals (BioMedNet- http://biomednet.com), CD-ROM (Current Content), Medline Search (Internet Grateful Med- http://igm.nlm.nih.gov), web connection to the National Library of Medicine, National Center for Biotechnology Information (PubMed- www.ncbi.nlm.nih.gov/pubmed) and simulations (PCGene) will be used during the course.
| BIOLOGY GRADING SCALE |
A = 90-100%
B = 80-89%
C = 70-79%
D = 60-69%
F = 0-59%
Your Final Grade for this course will be determined as follows:
Two (2) Lecture Exams (250 points each) = 500 total pointsJournal Club Participation and Presentation = 100 points
Homework/Library Assignments (3 X 50 points each) = 150 points
Three (3) Surprise Quizzes (50 points each) = 150 total points
Subjective: Class participation, attendance, etc. = 100 points
Total = 1000 total points possible plus bonus (if applicable)
Grade = Total points earned / 1000 x 100%
Note: All exams, quizzes and written assignments are the property of the School of Natural and Health Sciences, and will be retained by the instructor after reviewing the results with the students.
| Disability Statement: |
Students with documented special learning needs may want to inform the instructor so that accommodations may be made, or contact the Barry Office of Services for Students with Disabilities 305-899-3489.
| Academic Dishonesty Policy: |
Students should be aware that cheating on exams will not be tolerated. Any student caught giving or receiving assistance during an exam, or using cheat sheet, etc. will receive a grade of ZERO for that exam. This zero grade may not be dropped or made up; and WILL be used when determining the student's final grade. Any student caught cheating a second time will receive a grade of F for the course and will be referred to his/her Dean for disciplinary action. The same is true with respect for quizzes. A plagiarized written assignment will receive a grade of ZERO.
(For further information concerning the dishonesty policy, please refer to your Barry University 2002-2003 Catalog)
| Quizzes, Homework/Library Assignments: |
There will be three (3) surprise quizzes (worth 50 points each) and three (3) homework/library assignments (worth 50 points each) during the semester. These assignments may require library and/or Internet research to answer short problem questions or case study reports. Answers to these assignments should be brief, precise, and no more than one or two pages in length. Homework is due one week after the assignment is given. These assignments are important to your grade in this course and are intended to help guide your studying and to familiarize you with the recent and cutting edge scientific literature. Graded reports will be ready for you to review two weeks after the due day. Any assignment turned in late will be worth a maximum of 1/2 credit.
Reading assignments from the text are listed on the course syllabus to correspond with the material to be covered in class on a given week. The intent of the reading assignments is to reinforce the lecture material and to provide additional information and perspective. It is essential that you read the material for each section as it is not possible to cover all the appropriate material in class.
To gain the MOST benefit from the reading assignments, you should read the material before class. You will be responsible for the subject matter presented in class as well as the reading and Internet assignments for the exams. In studying for exams, use the lecture material as a guide as to the specific areas in the text to focus on.
| Class Attendance: |
Attendance is Mandatory.
You are expected to attend all classes. The student who is consistently late or absent will not have the same opportunities to ask questions as punctual students who attend each lecture and seminar. Therefore, consistent tardiness and/or absences will result in a significantly lower evaluation on class participation portion of the grade. Daily sign-in sheets will be provided for the student's protection. A record of students who arrive late for lecture will be kept. You are responsible for all material covered in lectures. If you miss classes, you cannot expect to do well in this course.
ABSENCE FROM CLASS IS NO EXCUSE FOR
MISUNDERSTANDINGS ABOUT EXAMS OR QUIZZES
| Mid-Term Exam and Final Exam: |
Each exam will consist of multiple choice, problem solving, matching, fill-in-the-blank, and short-essay questions. Material from the lectures AND the assigned readings will be included. The mid-term exam is scheduled for February 27, 2003. The Final Exam is scheduled for Thursday, May 8, 2003, 4:00 - 5:50 PM.
All make-up exams will be oral unless special arrangements are made by the student before hand.
BMS 632 (02) ENDOCRINOLOGY Spring 2003
Tentative Class Schedule:
| Week 1-4 pp.1-84 |
Date Topic
1/16 1. Introduction to the Endocrine system
1/23 2. Anterior Pituitary Gland
1/30 3. Posterior Pituitary Gland
2/6 4. Thyroid Gland
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MARC Research Symposium, February 13, 2003. 8:00AM-5:00PM
Andrea 111-112
2/13 5. Endocrine Pancreas
(First Assignment Due)
2/20 6. Review
(Graded Assignment return for review)
2/27 7. First Lecture Exam
3/6 8. NO CLASS, Spring Break
3/13 9. Endocrine Regulation of Calcium and Phosphate Metabolism
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3/20 10. Adrenal Gland
(Second Assignment Due)
3/27 11. Male Reproductive System
(Graded Assignment return for review)
4/3 12. Spermatogenesis
4/10 13. Female Reproductive System, Oogenesis
| Week 14-17 pp.177-225 |
4/17 14. Easter Holiday
4/24 15. Endocrinology of Pregnancy
5/1 16. Class Presentation
(Third Assignment Due)
5/8 17. Final Exam (4:00-5:50 PM)
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| Links and Assignments |
| Dr. Lin's Biology Links (framed version) |
| Assignments |
Endocrinology Links
| Endocrine Society http://www.endo-society.org/ |
http://www.endo-society.org/coolsite.htm
Endocrine Reviews, Endocrinology http://endo.edoc.com/end-bin/searchSearch The Endocrine Society Journals Online
Copyright © 1999 The Endocrine Society. All rights reserved
Username: desert Password: *******
(accessible for Full text without Password using On-Campus computer)
| UpToDate in Endocrinology and Diabetes www.uptodateinc.com |
| Medline Search: Internet Grateful Med-http://igm.nlm.nih.gov |
| PubMed NLM's search service to access the 9 million citations in MEDLINE and Pre-MEDLINE (with links to participating on-line journals), and other related databases. |
http://www.ncbi.nlm.nih.gov/PubMed/
| National Library of Medicine-http://www.nlm.nih.gov |
| National Center for Biotechnology Information www.ncbi.nlm.nih.gov |
| Online Mendelian Inheritance in Man- OMIM online database for genetic diseases- www.ncbi.nlm.nih.gov/Omim |
| Assignments: |
Homework/Library Assignment #1 (50 Points)
Due February 13, 2003
Copyright © 2000 by Annual Reviews
Search and View Full-text articles:
http://physiol.annualreviews.org/search.dtl(Only accessible using On-Campus computer or with Remote Access if Off-Campus) http://access.barry.edu
| Maria L. Dufau | |
| THE LUTEINIZING HORMONE RECEPTOR | |
| Annu. Rev. Physiol. 1998 60: 461-496. [Abstract] [Full Text] [pdf:Full Text] | |
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Homework/Library Assignment #2
Due March 20, 2003
| GAD and Type I Diabetes | |
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Science 1999 May 14; 284: 1085k (in This Week in Science) [Summary] [html version] |
Fig. 2. The effect of 
cell-specific
suppression of
GAD expression on the development of diabetes and insulitis
| Control of Autoimmune Diabetes
in NOD Mice by GAD Expression or Suppression in
Cells |
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|---|---|
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Ji-Won Yoon, Chang-Soon Yoon, Hye-Won Lim, Qi Quan Huang, Yup Kang, Kwang Ho Pyun, Kensuke Hirasawa, Robert S. Sherwin, and Hee-Sook Jun |
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Science 1999 May 14; 284: 1183-1187. (in Reports) [Abstract] [Full Text. html] [Full Text .pdf] |
Perspective
Gadfly autoantigen. Autoimmune diabetes develops in nonobese diabetic (NOD) mice when peptides derived from glutamic acid decarboxylase (GAD), which is expressed by the insulin-producing b-islet cells (blue) of the pancreas, are presented by antigen presenting cells (APCs) to T cells (A).
Harald von Boehmer and Adelaida Sarukhan
*http://www.sciencemag.org/cgi/content/full/284/5417/1135 [html version]
Science Volume 284, Number 5417 Issue of 14 May 1999, pp. 1135 - 1137
©1999 by The American Association for the Advancement of Science.
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Homework/Library Assignment #3
Due May 1, 2003
Steroidogenesis in Fundulus heteroclitus. II. Production of 17
alpha-hydroxy-20 beta-dihydroprogesterone, testosterone, and 17 beta-estradiol by various
components of the ovarian follicle.
Gen Comp Endocrinol. 1989 Nov;76(2):230-40.
PMID:
2591717; UI: 90076882
The Biology Place: http://www.biology.com
User ID- STU/lin
Password- *********
| Interactive Learning Activities: |
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| Reading Assignments : |
Primary Source Article
Copyright © 1999 by the American Association for the Advancement of Science
User Name: peterlin Password: ********
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Review Articles
Endocrine Reviews http://endo.edoc.com/end-bin/searchSearch The Endocrine Society Journals Online
Username: desert Password: *******
_________________________________________________
Copyright © 2000 by Annual Reviews
Search and View Full-text articles:
http://physiol.annualreviews.org/search.dtl(Only accessible using On-Campus computer)
__________________________________
Search Results: http://physiol.annualreviews.org/cgi/search?journalcode
| Maria L. Dufau | |
| THE LUTEINIZING HORMONE RECEPTOR | |
| Annu. Rev. Physiol. 1998 60: 461-496. [Abstract] [Full Text] | |
| Antti Kaipia and Aaron J. W. Hsueh | |
| REGULATION OF OVARIAN FOLLICLE ATRESIA | |
| Annu. Rev. Physiol. 1997 59: 349-363. [Abstract] [Full Text] | |
a) Introduction to the Endocrine System
Berridge MJ: Inositol trisphosphate and calcium signalling. Nature 361:351,
1993. PMID:
8381210; UI: 93149269
![[212 medline neighbors]](../images/relart.gif){kind=small}
Birnbaumer L: Receptor-to-effector signaling through G proteins: roles for beta-gamma dimers as well as alpha subunits. Cell 71:1069,1992.
Chin WW: Current concepts of thyroid hormone action: progress notes for the clinician. Thyroid Today 15(3):July/Aug/Sept 1992.
Hadcock JR, Malbon CC: Agonist regulation of gene expression of adrenergic receptors and G proteins. J Neurochem 60:1,1993.
Jones KE, Brubaker JH, Chin WW: Evidence that phosphorylation events participate in thyroid hormone action. Endocrinology 134:543, 1994.
Schuchard M, Landers JP, Sandhu NP, Speisberg TC: Steroid hormone regulation of nuclear proto-oncogenes, Endocr Rev 14:659, 1994.
Cell Signaling, G-Protein
Clapham DE, et al: New roles for G-protein beta gamma-dimers in transmembrane signalling. Nature. 1993 Sep 30;365(6445):403-6. Review.
Clapham DE, etal: G protein beta gamma subunits. Annu Rev Pharmacol Toxicol.
1997;37:167-203. Review.
PMID:
9131251; UI: 97277875
Berridge MJ: Elementary and global aspects of calcium signalling. J Exp Biol.
1997 Jan;200 ( Pt 2):315-9. Review.
PMID:
9050239; UI: 97202745
![[Journal of Experimental Biology]](../images/jeb-btn.gif){kind=small}
(Also on reserved in Barry Library)
b) Autocrine and Paracrine signals in the mammary gland
Salomon DS, etal: Oncogenes, growth factors, and growth inhibitors in breast cancer. Current Opinion in Endocrinology & Diabetes 1995; 2:500-509 (Article on reserved in Barry Library)
http://www.medscape.com/
c) Hormone-Sensitive and Hormone-Refractory Prostate Cancer http://www.medscape.com/moffitt/CancerControl/1998/v05.n06/cc0506.04.rago/cc0506.04.rago-01.html
Correlation Of P34cdc2 Cyclin-dependent Kinase Overexpression, Cd44s Downregulation,
And Her-2/neu Oncogene Amplification With Recurrence In Prostatic Adenocarcinomas. http://www.medscape.com/moffitt/CancerControl/1998/v05.n06/cc0506.09.pow/cc0506.09.pow-01.html
Fas-mediated Apoptosis In Seven Human Prostate Cancer Cell Lines: Correlation With Tumor Stage.
d) Exercise and Diabetes Evangelia Tsiani PhD and Adria Giacca MD [Full length article from Medscape] [Canadian Journal of Diabetes Care 22(4):39-46, 1998. Canadian Diabetes Association]
Primary Source Article
Scientific American (http://www.sciam.com)
BRCA1
BRCA1 required for transcription-coupled repair of oxidative DNA damage. Lori C. Gowen, Anna V. Avrutskaya, Anne M. Latour, Beverly H Koller, Steven A. Leadon. Science 281:1009-1012 (1998) (http://www.sciencemag.org)
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Thiessen | http://cherubino.med.jhmi.edu/~paul | University
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