NCBI Conserved Domain Database
PubMed Nucleotide Protein Structure CDD Taxonomy Help?
CD: cd00069.2, GHB, Query added PSSM-Id: 14805 Source: Smart
Description: Glycoprotein hormone beta chain homologues. Gonadotropins; reproductive hormones consisting of two glycosylated chains (alpha and beta) of similar topology with Cysteine-knot motifs.
Taxa:  Gnathostomata References: 3 Pubmed Links Related: smart00068, pfam00007
Status: curated CD Created: 1-Nov-2000 Updated: 21-Oct-2002
Aligned: 33 rows PSSM: 102 columns Representative: Consensus
Proteins: [Click here for CDART summary of Proteins containing cd00069]
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                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1       #                        #   #                  #           
consensus     1 CRPTNITIAVEKEECPVCVTINTTICAGYCYTKDPVYKSPLSPLPQRVCTYRELSYETVR 60
query        27 CQLLNQTISLEKRGCSGCHRVETTICSGYCATKDPNYKTSYNKAIQHVCTYGDLYYKTFE 86
1HRP_B        9 CRPINATLAVEkegCpvCITVNTTICAGYCPTMTRVLQgvlpaLPQVVCNYrdVRFESIR 68
gi 121732    30 CEPINETISVEkdgCpkCLVFQTSICSGHCITKDPSYKsplstVYQRVCTYrdVRYETVR 89
gi 126481     4 CHLANATISAEkdhCpvCITFTTSICTGYCQTMDPVYKtalssFKQNICTYkeIRYDTIK 63
gi 399831    27 CQLLNQTISLEkrgCsgCHRVETTICSGYCATKDPNYKtsynkAIQHVCTYgdLYYKTFE 86
gi 585227     6 CQLINQTVSVEkegCasCHPVETTICSGHCITKDPVIKipfskVYQHVCTYrdFYYKTFE 65
gi 1346202   30 CQPINQTVSLEkegCptCLVIQTPICSGHCFTKELVFKspfstVYQHVCTYrdVRYETIC 89
gi 8250132   22 CALENITIGIEkdgCgnCVSVNTTSCAGRCLTQADVYKssislYTQLVCTFkeISYVTVQ 81
gi 11132425   1 CELSNITIVLEkeeCgaCVSVNATWCSGYCYTKDANLMypqksEKQGVCTYteVIYETVK 60

                        70        80        90       100
                ....*....|....*....|....*....|....*....|..
Feature 1                          # #                    
consensus    61 LPGCPPGVDPGVTYPVALSCHCGKCNTDTTDCTVLSLGPPSC 102
query        87 FPECVPGVDPVVTYPVALSCRCGGCAMATSDCTFESLQPDFC 128
1HRP_B       69 LPGCprgvnPVVSYAVALSCQCALCRRStTDCGGPKDHPLTC 110
gi 121732    90 LPDCrpgvdPHVTFPVALSCDCNLCTMDtSDCAIQSLRPDFC 131
gi 126481    64 LPDClpgtdPFFTYPVALSCYCDLCKMDySDCTVESSEPDVC 105
gi 399831    87 FPECvpgvdPVVTYPVALSCRCGGCAMAtSDCTFESLQPDFC 128
gi 585227    66 LPDCppgvdPTVTYPVALSCHCGRCAMDtSDCTFESLQPDFC 107
gi 1346202   90 LPDCspwvdPHVTYPVALSCDCSLCNMDtSDCTIESLQPDLC 131
gi 8250132   82 LPNCpehvdPFYTYPVALSCECGQCATDyTDCGTLSLGPSDC 123
gi 11132425  61 IPGCaenvnPFYTYPVAVDCHCGRCDSEtTDCTVRALGPTYC 102

Feature 1: cysteine knot motif
Evidence: Comment: cysteine knot motif of glycoprotein hormone beta (GHB) subunit

Citing CDD: Marchler-Bauer A, Anderson JB, DeWeese-Scott C, Fedorova ND, Geer LY, He S, Hurwitz DI, Jackson JD, Jacobs AR, Lanczycki CJ, Liebert CA, Liu C, Madej T, Marchler GH, Mazumder R, Nikolskaya AN, Panchenko AR, Rao BS, Shoemaker BA, Simonyan V, Song JS, Thiessen PA, Vasudevan S, Wang Y, Yamashita RA, Yin JJ, Bryant SH (2003), "CDD: a curated Entrez database of conserved domain alignments", Nucleic Acids Res. 31: 383-387

 


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