NCBI Conserved Domain Database
PubMed Nucleotide Protein Structure CDD Taxonomy Help?
CD: cd00069.2, GHB, Query added PSSM-Id: 14805 Source: Smart
Description: Glycoprotein hormone beta chain homologues. Gonadotropins; reproductive hormones consisting of two glycosylated chains (alpha and beta) of similar topology with Cysteine-knot motifs.
Taxa:  Gnathostomata References: 3 Pubmed Links Related: smart00068, pfam00007
Status: curated CD Created: 1-Nov-2000 Updated: 21-Oct-2002
Aligned: 33 rows PSSM: 102 columns Representative: Consensus
Proteins: [Click here for CDART summary of Proteins containing cd00069]
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                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1       #                        #   #                  #           
consensus     1 CRPTNITIAVEKeeCPVCVTINTTICAGYCYTKDPVYKSPLSPLPQRVCTYrELSYETVR 60
query        20 CHLKNVSIPMER--CGQRVCIHTTICEGLCFSEDAVFESPDEAPEHRVCNG-DWSYEVKH 76
1HRP_B        9 CRPINATLAVEkegCpvCITVNTTICAGYCPTMTRVLQgvlpaLPQVVCNYrdVRFESIR 68
gi 399830    20 CHLKNVSIPMEr--CgqRVCIHTTICEGLCFSEDAVFEspdeaPEHRVCNGd-WSYEVKH 76
gi 585226     8 CHPKNISISVEs--CgiTEFILTTICEGQCYLEDPVYIs---hDEQKICNGd-WSYEVKH 61
gi 1346200   32 CRLNNMTITVEredC--HGSITITTCAGLCETTDLNYQstwlpRSQGACNFkeWSYEEVY 89
gi 2147429   23 CHPTNISIQVEs--CglTEVIYTTICEGQCYHEDLVYIshyerPEQRICTGd-WSYEVKH 79
gi 11133064  26 CRLTNISITVEseeCgsCITIDTTACAGLCKTQESVYRsplmlSYQNTCNFreWTYETYE 85
gi 11133227  23 CGLANISISVEneeCggCITFNTTACAGLCFTQDSVYKsslksYPQQACNFrdVVYETVH 82
gi 15077117  23 CRPKNISLPVD---T--CGFVDTTICEGQCFQKDPNFIhtddwPKQKTCNGe-WSYEVKY 76

                        70        80        90       100
                ....*....|....*....|....*....|....*....|..
Feature 1                          # #                    
consensus    61 LPGCPPgvdPGVTYPVALSCHCGKCNTDTTDCTVLSLGPPSC 102
query        77 IQGCPE----SITYPVATNCYCSACNTKDTYCTRLYAHIPSC 114
1HRP_B       69 LPGCprgvnPVVSYAVALSCQCALCRRStTDCGGPKDHPLTC 110
gi 399830    77 IQGCp----ESITYPVATNCYCSACNTKdTYCTRLYAHIPSC 114
gi 585226    62 IEGCp----VGVTYPVARNCECTACNTGnTYCGRLPGYVPSC 99
gi 1346200   90 LEGCpp-gaNPFFIPVAKSCDCIKCKTDnTDCDRISMATPSC 130
gi 2147429   80 IKGCp----VGVTYPVARNCECTTCNTEnTACGRFPEDIPSC 117
gi 11133064  86 FKGCparadSIFTYPVALSCECSKCNSDiTDCGVLSQQTLGC 127
gi 11133227  83 LPGCpsgmdLHFTYPVALSCECSKCNTDsTDCGPLNTEVSGC 124
gi 15077117  77 TEQCp----RGFIYPVARKCECTACNAN-TDCGTLSGYIPSC 113

Feature 1: cysteine knot motif
Evidence: Comment: cysteine knot motif of glycoprotein hormone beta (GHB) subunit

Citing CDD: Marchler-Bauer A, Anderson JB, DeWeese-Scott C, Fedorova ND, Geer LY, He S, Hurwitz DI, Jackson JD, Jacobs AR, Lanczycki CJ, Liebert CA, Liu C, Madej T, Marchler GH, Mazumder R, Nikolskaya AN, Panchenko AR, Rao BS, Shoemaker BA, Simonyan V, Song JS, Thiessen PA, Vasudevan S, Wang Y, Yamashita RA, Yin JJ, Bryant SH (2003), "CDD: a curated Entrez database of conserved domain alignments", Nucleic Acids Res. 31: 383-387

 


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