NCBI Conserved Domain Database
PubMed Nucleotide Protein Structure CDD Taxonomy Help?
CD: smart00204.10, TGFB, Query added PSSM-Id: 22704 Source: Smart
Description: Transforming growth factor-beta (TGF-beta) family; Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types.
Taxa:  Bilateria References: 4 Pubmed Links Related: pfam00019
Status: Alignment from source Created: 12-Dec-2003
Aligned: 35 rows PSSM: 102 columns Representative: Consensus
Proteins: [Click here for CDART summary of Proteins containing smart00204]
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                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
consensus     1 CRRHDLYVDFKDLGWDDWIIAPKGYNAYYCEGECPFPLSERLN--AT--NHAIVQSLVHA 56
query         1 CCRQQFYIDFRLIGWNDWIIAPSGYFGNYCEGNCPAYMAGVPGsaSS--FHTAVVNQYRM 58
1NYS_B       11 CCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSG--SSlsFHSTVINHYRM 68
gi 118409   487 CRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFN--ST--NHAVVQTLVNN 542
gi 2501171  271 CRRRQMYVDFGSVGWNDWIVAPLGYDAYYCGGECEYPIPDHMN--TT--NHAIVQSLVNS 326
gi 585194   266 CHRHQLFINFQDLGWHKWVIAPKGFMANYCHGECPFSMTTYLN--SS--NYAFMQALMHM 321
gi 1170523  304 CCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPG--SAssFHTAVVNQYRM 361
gi 1708438  247 CCRQEFFVDFREIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPG--IAasFHTAVLNLLKA 304
gi 1161334  288 CQRHPLYVDFEEIGWSGWIISPRGYNAYHCKGSCPFPLGQNMR--PT--NHATVQSIINA 343
gi 18266881 294 CQRHRLFVSFRDVGWENWIIAPMGYQAYYCDGECPFPLGERLN--GT--NHAIIQTLVNS 349

                        70        80        90       100
                ....*....|....*....|....*....|....*....|....*....
consensus    57 LDPG--AVP-KPCCVPTKLSPLSMLYYDDDGNVVLRNYPNMVVEECGCR 102
query        59 RGMS--PGSmNSCCIPTKLSTMSMLYFDDEYNIVKR------------- 92
1NYS_B       69 RGHSpfANL-KSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS 116
gi 118409   543 MNPGk--VP-KACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGCR 588
gi 2501171  327 MKPKe--VP-GPCCVPTQLGQMSMLYLGSDGSVILKNYKEMVVVGCGCR 372
gi 585194   322 ADP---KVP-KAVCVPTKLSPISMLYQDSDKNVILRHYEDMVVDECGCG 366
gi 1170523  362 RGLNp-GTV-NSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGCA 408
gi 1708438  305 NTAAgtTGG-GSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGCS 352
gi 1161334  344 LKLTk-gVS-SPCCVPDKLFSINLLYFDDDENVVLKQYDDMVAGSCGCH 390
gi 18266881 350 IDNR--AVP-KVCCAPTKLSGISMLYFDNNENVVLRQYEDMVVEACGCR 395

Citing CDD: Marchler-Bauer A, Anderson JB, DeWeese-Scott C, Fedorova ND, Geer LY, He S, Hurwitz DI, Jackson JD, Jacobs AR, Lanczycki CJ, Liebert CA, Liu C, Madej T, Marchler GH, Mazumder R, Nikolskaya AN, Panchenko AR, Rao BS, Shoemaker BA, Simonyan V, Song JS, Thiessen PA, Vasudevan S, Wang Y, Yamashita RA, Yin JJ, Bryant SH (2003), "CDD: a curated Entrez database of conserved domain alignments", Nucleic Acids Res. 31: 383-387

 


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