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Download to Citation Manager Alert me when: new articles cite this article   Search for similar articles in:   Science Online Search Medline for articles by:   This article appears in the following Subject Collections: Immunology In type I diabetes, the immune system destroys the insulin-producing b cells of the pancreas. T cells to specific antigens develop--those recognizing glutamic acid decarboxylase (GAD) appear early in disease. Transfer of these T cells to nondiabetic animals can initiate disease. Yoon et al. (p. 1183; see the Perspective by Boehmer and Sarukhan) report that expression of GAD in b cells is required for the development of diabetes in NOD mice, the mouse model of type I diabetes. A series of mice were developed that expressed increasing amounts of an antisense gene to GAD messenger RNA. When expression was high, little GAD was detected on the b cells, and the NOD mice did not develop diabetes. Transfer of b cells from these mice into diabetic NOD mice cured NOD diabetes. Thus, not only was GAD necessary for the development of diabetogenic T cells, but the b cells were not destroyed in mice with ongoing disease unless they expressed GAD.   Download to Citation Manager Alert me when: new articles cite this article   Search for similar articles in:   Science Online Search Medline for articles by:   This article appears in the following Subject Collections: Immunology Volume 284, Number 5417, Issue of 14 May 1999, p. 1085. Copyright © 1999 by The American Association for the Advancement of Science. All rights reserved.